PoplarV1, Main, Exploration, bibRecord, 000F59

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania.

Identifieur interne : 000F59 ( Main/Exploration ); précédent : 000F58; suivant : 000F60

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania.

Auteurs : Orwa Dandash [Australie] ; Murat Yücel [Australie] ; Rothanthi Daglas [Australie] ; Christos Pantelis [Australie] ; Patrick Mcgorry [Australie] ; Michael Berk [Australie] ; Alex Fornito [Australie]

Source :

Translational psychiatry [ 2158-3188 ] ; 2018.

RBID : pubmed:29507281

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Antimaniacodépressifs (administration et posologie), Antimaniacodépressifs (pharmacologie), Cervelet (effets des médicaments et des substances chimiques), Cervelet (imagerie diagnostique), Cervelet (physiopathologie), Composés du lithium (administration et posologie), Composés du lithium (pharmacologie), Connectome (méthodes), Corps strié (effets des médicaments et des substances chimiques), Corps strié (imagerie diagnostique), Corps strié (physiopathologie), Cortex préfrontal (effets des médicaments et des substances chimiques), Cortex préfrontal (imagerie diagnostique), Cortex préfrontal (physiopathologie), Femelle (MeSH), Fumarate de quétiapine (administration et posologie), Fumarate de quétiapine (pharmacologie), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Méthode en simple aveugle (MeSH), Thalamus (effets des médicaments et des substances chimiques), Thalamus (imagerie diagnostique), Thalamus (physiopathologie), Trouble bipolaire (imagerie diagnostique), Trouble bipolaire (physiopathologie), Trouble bipolaire (traitement médicamenteux), Études de suivi (MeSH).
MESH :
- administration et posologie : Antimaniacodépressifs, Composés du lithium, Fumarate de quétiapine.
- effets des médicaments et des substances chimiques : Cervelet, Corps strié, Cortex préfrontal, Thalamus.
- imagerie diagnostique : Cervelet, Corps strié, Cortex préfrontal, Thalamus, Trouble bipolaire.
- méthodes : Connectome.
- pharmacologie : Antimaniacodépressifs, Composés du lithium, Fumarate de quétiapine.
- physiopathologie : Cervelet, Corps strié, Cortex préfrontal, Thalamus, Trouble bipolaire.
- traitement médicamenteux : Trouble bipolaire.
- Adolescent, Adulte, Femelle, Humains, Imagerie par résonance magnétique, Jeune adulte, Mâle, Méthode en simple aveugle, Études de suivi.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Antimanic Agents (administration & dosage), Antimanic Agents (pharmacology), Bipolar Disorder (diagnostic imaging), Bipolar Disorder (drug therapy), Bipolar Disorder (physiopathology), Cerebellum (diagnostic imaging), Cerebellum (drug effects), Cerebellum (physiopathology), Connectome (methods), Corpus Striatum (diagnostic imaging), Corpus Striatum (drug effects), Corpus Striatum (physiopathology), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Lithium Compounds (administration & dosage), Lithium Compounds (pharmacology), Magnetic Resonance Imaging (MeSH), Male (MeSH), Prefrontal Cortex (diagnostic imaging), Prefrontal Cortex (drug effects), Prefrontal Cortex (physiopathology), Quetiapine Fumarate (administration & dosage), Quetiapine Fumarate (pharmacology), Single-Blind Method (MeSH), Thalamus (diagnostic imaging), Thalamus (drug effects), Thalamus (physiopathology), Young Adult (MeSH).
MESH :
- chemical , administration & dosage : Antimanic Agents, Lithium Compounds, Quetiapine Fumarate.
- chemical , pharmacology : Antimanic Agents, Lithium Compounds, Quetiapine Fumarate.
- diagnostic imaging : Bipolar Disorder, Cerebellum, Corpus Striatum, Prefrontal Cortex, Thalamus.
- drug effects : Cerebellum, Corpus Striatum, Prefrontal Cortex, Thalamus.
- drug therapy : Bipolar Disorder.
- methods : Connectome.
- physiopathology : Bipolar Disorder, Cerebellum, Corpus Striatum, Prefrontal Cortex, Thalamus.
- Adolescent, Adult, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Single-Blind Method, Young Adult.

Abstract

Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and quetiapine are effective treatments for mania but their neurobiological effects remain largely unknown. We conducted a single-blinded randomized controlled maintenance trial in 61 FEM patients and 30 healthy controls. Patients were stabilized for a minimum of 2 weeks on lithium plus quetiapine then randomly assigned to either lithium (serum level 0.6 mmol/L) or quetiapine (dosed up to 800 mg/day) treatment for 12 months. Resting-state fMRI was acquired at baseline, 3 months (patient only) and 12 months. The effects of treatment group, time and their interaction, on striatal functional connectivity were assessed using voxel-wise general linear modelling. At baseline, FEM patients showed reduced connectivity in the dorsal (p = 0.05) and caudal (p = 0.008) cortico-striatal systems when compared to healthy controls at baseline. FEM patients also showed increased connectivity in a circuit linking the ventral striatum with the medial orbitofrontal cortex, cerebellum and thalamus (p = 0.02). Longitudinally, we found a significant interaction between time and treatment group, such that lithium was more rapid, compared to quetiapine, in normalizing abnormally increased functional connectivity, as assessed at 3-month and 12-month follow-ups. The results suggest that FEM is associated with reduced connectivity in dorsal and caudal corticostriatal systems, as well as increased functional connectivity of ventral striatal systems. Lithium appears to act more rapidly than quetiapine in normalizing hyperconnectivity of the ventral striatum with the cerebellum. The study was registered on the Australian and New Zealand Clinical Trials Registry (ACTRN12607000639426). http://www.anzctr.org.au.

DOI: 10.1038/s41398-018-0108-8
PubMed: 29507281
PubMed Central: PMC5838223

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000F40
to stream Main, to step Curation: 000F40

Le document en format XML

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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Yucel, Murat" sort="Yucel, Murat" uniqKey="Yucel M" first="Murat" last="Yücel">Murat Yücel</name>
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<country xml:lang="fr">Australie</country>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Daglas, Rothanthi" sort="Daglas, Rothanthi" uniqKey="Daglas R" first="Rothanthi" last="Daglas">Rothanthi Daglas</name>
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<affiliation wicri:level="4"><nlm:affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Pantelis, Christos" sort="Pantelis, Christos" uniqKey="Pantelis C" first="Christos" last="Pantelis">Christos Pantelis</name>
<affiliation wicri:level="1"><nlm:affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, VIC, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
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<author><name sortKey="Mcgorry, Patrick" sort="Mcgorry, Patrick" uniqKey="Mcgorry P" first="Patrick" last="Mcgorry">Patrick Mcgorry</name>
<affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052</wicri:regionArea>
<wicri:noRegion>3052</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name>
<affiliation wicri:level="1"><nlm:affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<wicri:noRegion>3052</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, 3220</wicri:regionArea>
<wicri:noRegion>3220</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health Clinical Program, 35 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen Youth Health Clinical Program, 35 Poplar Road, Parkville, VIC, 3052</wicri:regionArea>
<wicri:noRegion>3052</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Barwon Health and the Geelong Clinic, Swanston Centre, Geelong, VIC, 3220, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<wicri:noRegion>3220</wicri:noRegion>
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<author><name sortKey="Fornito, Alex" sort="Fornito, Alex" uniqKey="Fornito A" first="Alex" last="Fornito">Alex Fornito</name>
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<wicri:regionArea>Brain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, 3168</wicri:regionArea>
<wicri:noRegion>3168</wicri:noRegion>
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<idno type="eISSN">2158-3188</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Antimanic Agents (administration & dosage)</term>
<term>Antimanic Agents (pharmacology)</term>
<term>Bipolar Disorder (diagnostic imaging)</term>
<term>Bipolar Disorder (drug therapy)</term>
<term>Bipolar Disorder (physiopathology)</term>
<term>Cerebellum (diagnostic imaging)</term>
<term>Cerebellum (drug effects)</term>
<term>Cerebellum (physiopathology)</term>
<term>Connectome (methods)</term>
<term>Corpus Striatum (diagnostic imaging)</term>
<term>Corpus Striatum (drug effects)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lithium Compounds (administration & dosage)</term>
<term>Lithium Compounds (pharmacology)</term>
<term>Magnetic Resonance Imaging (MeSH)</term>
<term>Male (MeSH)</term>
<term>Prefrontal Cortex (diagnostic imaging)</term>
<term>Prefrontal Cortex (drug effects)</term>
<term>Prefrontal Cortex (physiopathology)</term>
<term>Quetiapine Fumarate (administration & dosage)</term>
<term>Quetiapine Fumarate (pharmacology)</term>
<term>Single-Blind Method (MeSH)</term>
<term>Thalamus (diagnostic imaging)</term>
<term>Thalamus (drug effects)</term>
<term>Thalamus (physiopathology)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Antimaniacodépressifs (administration et posologie)</term>
<term>Antimaniacodépressifs (pharmacologie)</term>
<term>Cervelet (effets des médicaments et des substances chimiques)</term>
<term>Cervelet (imagerie diagnostique)</term>
<term>Cervelet (physiopathologie)</term>
<term>Composés du lithium (administration et posologie)</term>
<term>Composés du lithium (pharmacologie)</term>
<term>Connectome (méthodes)</term>
<term>Corps strié (effets des médicaments et des substances chimiques)</term>
<term>Corps strié (imagerie diagnostique)</term>
<term>Corps strié (physiopathologie)</term>
<term>Cortex préfrontal (effets des médicaments et des substances chimiques)</term>
<term>Cortex préfrontal (imagerie diagnostique)</term>
<term>Cortex préfrontal (physiopathologie)</term>
<term>Femelle (MeSH)</term>
<term>Fumarate de quétiapine (administration et posologie)</term>
<term>Fumarate de quétiapine (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Imagerie par résonance magnétique (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Méthode en simple aveugle (MeSH)</term>
<term>Thalamus (effets des médicaments et des substances chimiques)</term>
<term>Thalamus (imagerie diagnostique)</term>
<term>Thalamus (physiopathologie)</term>
<term>Trouble bipolaire (imagerie diagnostique)</term>
<term>Trouble bipolaire (physiopathologie)</term>
<term>Trouble bipolaire (traitement médicamenteux)</term>
<term>Études de suivi (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antimanic Agents</term>
<term>Lithium Compounds</term>
<term>Quetiapine Fumarate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimanic Agents</term>
<term>Lithium Compounds</term>
<term>Quetiapine Fumarate</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antimaniacodépressifs</term>
<term>Composés du lithium</term>
<term>Fumarate de quétiapine</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Bipolar Disorder</term>
<term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Prefrontal Cortex</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Prefrontal Cortex</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bipolar Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Cervelet</term>
<term>Corps strié</term>
<term>Cortex préfrontal</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Cervelet</term>
<term>Corps strié</term>
<term>Cortex préfrontal</term>
<term>Thalamus</term>
<term>Trouble bipolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Connectome</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Connectome</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antimaniacodépressifs</term>
<term>Composés du lithium</term>
<term>Fumarate de quétiapine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cervelet</term>
<term>Corps strié</term>
<term>Cortex préfrontal</term>
<term>Thalamus</term>
<term>Trouble bipolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Bipolar Disorder</term>
<term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Prefrontal Cortex</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Trouble bipolaire</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Single-Blind Method</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en simple aveugle</term>
<term>Études de suivi</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and quetiapine are effective treatments for mania but their neurobiological effects remain largely unknown. We conducted a single-blinded randomized controlled maintenance trial in 61 FEM patients and 30 healthy controls. Patients were stabilized for a minimum of 2 weeks on lithium plus quetiapine then randomly assigned to either lithium (serum level 0.6 mmol/L) or quetiapine (dosed up to 800 mg/day) treatment for 12 months. Resting-state fMRI was acquired at baseline, 3 months (patient only) and 12 months. The effects of treatment group, time and their interaction, on striatal functional connectivity were assessed using voxel-wise general linear modelling. At baseline, FEM patients showed reduced connectivity in the dorsal (p = 0.05) and caudal (p = 0.008) cortico-striatal systems when compared to healthy controls at baseline. FEM patients also showed increased connectivity in a circuit linking the ventral striatum with the medial orbitofrontal cortex, cerebellum and thalamus (p = 0.02). Longitudinally, we found a significant interaction between time and treatment group, such that lithium was more rapid, compared to quetiapine, in normalizing abnormally increased functional connectivity, as assessed at 3-month and 12-month follow-ups. The results suggest that FEM is associated with reduced connectivity in dorsal and caudal corticostriatal systems, as well as increased functional connectivity of ventral striatal systems. Lithium appears to act more rapidly than quetiapine in normalizing hyperconnectivity of the ventral striatum with the cerebellum. The study was registered on the Australian and New Zealand Clinical Trials Registry (ACTRN12607000639426). http://www.anzctr.org.au.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29507281</PMID>
<DateCompleted><Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>03</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2158-3188</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>03</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Translational psychiatry</Title>
<ISOAbbreviation>Transl Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania.</ArticleTitle>
<Pagination><MedlinePgn>59</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41398-018-0108-8</ELocationID>
<Abstract><AbstractText>Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and quetiapine are effective treatments for mania but their neurobiological effects remain largely unknown. We conducted a single-blinded randomized controlled maintenance trial in 61 FEM patients and 30 healthy controls. Patients were stabilized for a minimum of 2 weeks on lithium plus quetiapine then randomly assigned to either lithium (serum level 0.6 mmol/L) or quetiapine (dosed up to 800 mg/day) treatment for 12 months. Resting-state fMRI was acquired at baseline, 3 months (patient only) and 12 months. The effects of treatment group, time and their interaction, on striatal functional connectivity were assessed using voxel-wise general linear modelling. At baseline, FEM patients showed reduced connectivity in the dorsal (p = 0.05) and caudal (p = 0.008) cortico-striatal systems when compared to healthy controls at baseline. FEM patients also showed increased connectivity in a circuit linking the ventral striatum with the medial orbitofrontal cortex, cerebellum and thalamus (p = 0.02). Longitudinally, we found a significant interaction between time and treatment group, such that lithium was more rapid, compared to quetiapine, in normalizing abnormally increased functional connectivity, as assessed at 3-month and 12-month follow-ups. The results suggest that FEM is associated with reduced connectivity in dorsal and caudal corticostriatal systems, as well as increased functional connectivity of ventral striatal systems. Lithium appears to act more rapidly than quetiapine in normalizing hyperconnectivity of the ventral striatum with the cerebellum. The study was registered on the Australian and New Zealand Clinical Trials Registry (ACTRN12607000639426). http://www.anzctr.org.au.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dandash</LastName>
<ForeName>Orwa</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Brain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, 3168, Australia. orwa.dandash@unimelb.edu.au.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia. orwa.dandash@unimelb.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yücel</LastName>
<ForeName>Murat</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Brain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, 3168, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daglas</LastName>
<ForeName>Rothanthi</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pantelis</LastName>
<ForeName>Christos</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-9565-0238</Identifier>
<AffiliationInfo><Affiliation>Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Florey Institute for Neuroscience and Mental Health, Kenneth Myer Building, Royal Parade, Parkville, VIC, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McGorry</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berk</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5554-6946</Identifier>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, VIC, 3220, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Orygen Youth Health Clinical Program, 35 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Barwon Health and the Geelong Clinic, Swanston Centre, Geelong, VIC, 3220, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fornito</LastName>
<ForeName>Alex</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Brain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC, 3168, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ANZCTR</DataBankName>
<AccessionNumberList><AccessionNumber>ACTRN12607000639426</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>03</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Transl Psychiatry</MedlineTA>
<NlmUniqueID>101562664</NlmUniqueID>
<ISSNLinking>2158-3188</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018692">Antimanic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018020">Lithium Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>2S3PL1B6UJ</RegistryNumber>
<NameOfSubstance UI="D000069348">Quetiapine Fumarate</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018692" MajorTopicYN="N">Antimanic Agents</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001714" MajorTopicYN="N">Bipolar Disorder</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002531" MajorTopicYN="N">Cerebellum</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063132" MajorTopicYN="N">Connectome</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018020" MajorTopicYN="N">Lithium Compounds</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017397" MajorTopicYN="N">Prefrontal Cortex</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069348" MajorTopicYN="N">Quetiapine Fumarate</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>04</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>12</Month>
<Day>30</Day>
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<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>10</Month>
<Day>28</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
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Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania.

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania.

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